In order to apply the M.A.A.R.I.E. framework to a meta-analysis we will examine the following article:

Montalescot GM, Borentain M, Payot L, et al. Early vs Late Administration of Glycoprotein IIb/IIIa Inhibitors in Primary Percutaneous Coronary Intervention of Acute ST-Segment Elevation Myocardial Infarction- A Meta-Analysis. JAMA 2004;292:362-366.

If you do not have access to the journal, you can obtain the article at Journal of the American Medical Association (JAMA).

This article, like the others chosen for this site, is well-conducted research from a respected research journal that illustrates many important study design issues.

The exercise will ask you each of the 18 questions of the M.A.A.R.I.E. framework for Studying a Study. You'll have the opportunity to provide your own answer, compare your answer to the suggested answer, and get "help" if you don't know the answer.

So let's begin.