The M.A.A.R.I.E. framework outlined below is the basis for a step-by-step approach to reading the clinical research literature. Each of the 6 elements includes 3 Questions to Ask.

Uncover these questions by clicking on each of the M.A.A.R.I.E. framework buttons at the top of the graphic below, ideally starting with Method and working your way across.

The six elements of the M.A.A.R.I.E. framework and the three questions associated with each element form the basis for a step-by-step approach to reading the medical evidence. You are now ready to practice this approach on four different types of studies using real journal articles. These study types are case control studies, cohort studies, randomized clinical trials, and meta-analysis.