Uncover these questions by clicking on each of the M.A.A.R.I.E. framework buttons below, ideally starting with Method and working your way across.

The six elements of the M.A.A.R.I.E. framework and the three questions associated with each element form the basis for a step-by-step approach to reading the medical evidence. You are now ready to practice this approach using a real journal article on cost-effectiveness.